Azor

Azor is a prescription medication used to treat hypertension, or high blood pressure. It contains 2 medications, amlodipine and olmesartan. Amlodipine, a calcium channel blocker, and olmesartan, an angiotensin II receptor blocker (ARB), both work by relaxing veins and arteries so that blood can more easily pass through them. This medication comes in tablet form and is taken once a day, with or without food.

Common side effects of Azor include swelling, flushing, and palpitations (a pounding or racing heartbeat). Azor can cause dizziness and drowsiness. Do not drive or operate heavy machinery until you know how Azor affects you.

Azor is a prescription medication used to treat high blood pressure, known medically as hypertension.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

• Daiichi Sankyo, Inc.

Serious side effects have been reported with Azor. See the “Drug Precautions” section.

Common side effects of Azor include:

• low blood pressure
• flushing of the cheeks
• palpitations (a pounding or racing heartbeat)
• drowsiness
• dizziness or orthostasis (feeling lightheaded when rising from a sitting or lying down position)

This is not a complete list of Azor side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• simvastatin (Zocor)
• colesevelam (WelChol)
• potassium-sparing diuretics such as:
  • spironolactone (Aldactone)
  • triamterene (Dyrenium)
  • amiloride (Midamor)
• angiotensin-converting enzyme (ACE) inhibitors such as:
  • benazepril (Lotensin, Lotensin HCT)
  • captopril (Capoten, Capozide)
  • enalapril (Vasotec, Vaseretic)
  • fosinopril (Monopril, Monopril HCT)
  • lisinopril (Prinivil, Prinzide, Zestril, Zestoretic)
  • moexipril (Univasc, Uniretic)
  • quinapril (Accupril, Accuretic, Quinaretic)
  • ramipril (Altace)
  • trandolapril (Mavik, Tarka)
• other angiotensin receptor II blockers such as:
  • azilsartan (Edarbi)
  • candesartan (Atacand)
  • irbesartan (Avapro)
  • losartan (Cozaar)
  • olmesartan (Benicar)
  • telmisartan (Micardis, Twynsta)
  • valsartan (Diovan)
• aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs) such as:
  • celecoxib (Celebrex)
  • diclofenac (Cambia, Cataflam, Flector, Voltaren, Zipsor and others)
  • etodolac (Lodine)
  • ibuprofen (Advil, Motrin, Nuprin)
  • indomethacin (Indocin, Indocin SR)
  • ketoprofen (Orudis, Actron, Oruvail)
  • ketorolac (Toradol)
  • meloxicam (Mobic)
  • nabumetone (Relafen)
  • naproxen (Naprosyn)
  • naproxen sodium (Aleve, Anaprox, Naprelan)
  • oxaprozin (Daypro)
  • piroxicam (Feldene)
• potassium supplements
• aliskiren (Tekturna,Tekturna HCT, Amturnide, Tekamlo, Valturna)

This is not a complete list of Azor drug interactions. Ask your doctor or pharmacist for more information.

Serious side effects have been reported with Azor including:

• hypotension. Excessive sweating and dehydration may lead to an excessive fall in blood pressure (hypotension). Vomiting or diarrhea may also lead to a fall in blood pressure.
• coronary artery disease (CAD). When starting or increasing the dose of Azor, those with CAD may experience an increase in the frequency, duration, or severity of chest pain or a heart attack if these events do happen to occur.
• decline in kidney function. Your doctor may need to perform tests to determine the stability of the function of your kidneys, especially in patients who already have kidney dysfunction. In addition, It is recommended to avoid use of both Azor and the medication aliskiren if you already have kidney impairment.
• liver dysfunction. Since amlodipine (an active ingredient in Azor) is broken down by the liver, your doctor may need to exercise extra caution when choosing the dose of Azor in those with severe liver dysfunction.
• severe diarrhea and weight loss. Severe, chronic diarrhea with considerable weight loss may develop months to years after starting Tribenzor. Tell your doctor if you are experiencing these symptoms.

Azor can cause dizziness and drowsiness. Do not drive or operate heavy machinery until you know how Azor affects you.

Do not take Azor if you:

• are allergic to Azor or any of this medication’s ingredients
• are diabetic and also taking aliskiren (Tekturna, Tekturna HCT, Amturnide, Tekamlo, Valturna)

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Azor, salt substitutes containing potassium should be avoided.

Before taking Azor, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

• are allergic to Azor or any of this medication’s ingredients
• are taking aliskiren (Tekturna, Tekturna HCT, Amturnide, Tekamlo, Valturna)
• have kidney or liver dysfunction
• have heart problems such as CAD or heart failure
• are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Azor falls into category D. Azor is not usually recommended for use during pregnancy. See the “FDA Warning” section.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known whether the components of Azor can pass into human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or to discontinue the drug. The importance of the drug to the mother should be taken into account.

• Take Azor exactly as prescribed.
• This medication comes in tablet form and is taken once a day, with or without food. If stomach upset occurs, it is recommended to take with food.
• It is best to take Azor at the same time everyday.
• If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Azor at the same time.

• Take Azor exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. The recommended starting dose of Azor is 5/20 mg once daily.
• Your doctor may increase your dose as necessary to achieve the desired blood pressure.
• The maximum recommended dose of Azor is 10/40 mg once daily.

If you take too much Azor call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

• Store Azor at room temperature between 15-30°C (59-86°F).
• Keep this medication out of the reach of children.

Fetal Toxicity:

• When pregnancy is detected, discontinue Azor as soon as possible.
• Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.