Cocaine hydrochloride

Cocaine hydrochloride is a prescription medication used as a local (topical) anesthetic to numb the mucous membranes of the oral (mouth), laryngeal (voice box), and nasal (nose) cavities. 

Cocaine hydrochloride belongs to a group of medications called local anesthetics. These work by blocking the pain signals to the brain. 

This medication is available in a 4% and 10%  topical solution to be directly applied to the area that needs to be anesthetized (numbed) by a healthcare professional.

THIS DRUG HAS NOT BEEN FOUND BY FDA TO BE SAFE AND EFFECTIVE.

Cocaine hydrochloride is a prescription medication used as a local (topical) anesthetic to numb the mucous membranes of the oral (mouth), laryngeal (voice box), and nasal (nose) cavities. 

Serious side effects have been reported with cocaine hydrochloride topical solution. See the “Cocaine Hydrochloride Precautions” section.

Cocaine hydrochloride topical solution may cause dead skin tissue.

Although cocaine hydrochloride solution is applied topically, systemic side effects may be evident such as:

• Nervousness
• Restlessness
• Excitement
• Euphoria
• Confusion
• Agitation
• Hallucinations

This is not a complete list of cocaine hydrochloride side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• antidepressants
• chlorpromazine (Thorazine)
• indomethacin (Indocin)
• monoamine oxidase inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), and rasagiline (Azilect)
• methyldopa
• naloxone (Evzio)
• reserpine
• other local anesthetics

This is not a complete list of cocaine hydrochloride drug interactions. Ask your doctor or pharmacist for more information.

• Central nervous system side effects which may include:
  • Nervousness
  • Restlessness
  • Excitement
  • Tremors
  • Tonic-clonic seizures
  • Vomiting
  • Respiratory failure 
• Change in heart rate. Small doses of cocaine slow the heart rate, but after moderate doses, the heart rate is increased. 
• Increased body temperature
• Contracted blood vessels
• Dilated pupils (mydriasis)

This drug is not meant for ophthalmic (eye) use, because it can cause damage to the clear outer part of the eye (cornea).

Cocaine hydrochloride topical solution should not be used if you are allergic to cocaine or to the components of the topical solution. 

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements

Tell your doctor if you are breastfeeding or plan to breastfeed.

Studies have shown that cocaine is detectable in breast milk after recreational use by breastfeeding mothers. Adverse reactions in nursing infants from cocaine use are possible. 

Breast feeding is not recommended in the chronic cocaine abuser & occasional use is discouraged during breast feeding.

With that being said, due to the possibility of rapid and excessive absorption of the drug following topical application, a choice should be made whether to stop nursing or to not use this medication. 

This medication is available in a 4% and 10%  topical solution to be directly applied to the area that needs to be anesthetized (numbed) by a healthcare professional.

The dosage varies and depends upon the area to be anesthetized (numbed) and other factors. Your healthcare provider should administered the lowest dosage needed to provide effective anesthesia.

Dosages should be reduced for children, the elderly, and for debilitated patients.

Cocaine hydrochloride topical solution can be administered with cotton applicators or packs, instilled into a cavity, or as a spray.

If cocaine hydrochloride topical solution is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. Your healthcare provider should have special emergency equipment and drugs immediately available at the medical setting where this medication is administered. 

Cocaine hydrochloride topical solution is not for injection or ophthalmic (eye) use.