Emend

Emend is a prescription medication used to prevent nausea and vomiting that may occur within 24 hours after receiving chemotherapy treatment. It is also used with other medications to prevent delayed nausea and vomiting that may occur several days after receiving chemotherapy medications. Emend is also used to prevent nausea and vomiting caused by surgery. Emend  belongs to a group of drugs called antiemetics. These work by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.

This medication comes as a capsule and an injection.

The capsule is taken by mouth usually once daily, with or without food. To prevent nausea and vomiting due to chemotherapy, you will probably take Emend 1 hour before your first dose of chemotherapy, and then each morning for the next 2 days. To prevent nausea and vomiting caused by surgery, Emend is usually taken as one dose within 3 hours before the start of surgery.

The injection is given either on day 1 with the capsule taken on days 2 and 3 or the injection is given on day 1 and no capsules are taken on the following days. 

Common side effects of the capsule include constipation, itching, and tiredness. Common side effects of the injection include hiccups, tiredness, and changes in liver function blood tests. Do not drive or operate heavy machinery until you know how Emend affects you.

Emend is a prescription medicine used in adults to prevent nausea and vomiting:

Capsule:

• prevent nausea and vomiting that may occur within 24 hours after receiving chemotherapy treatment
• prevent delayed nausea and vomiting that may occur several days after receiving chemotherapy medications
• prevent nausea and vomiting caused by surgery

​Injection:

• prevent nausea and vomiting that may occur within 24 hours after receiving chemotherapy treatment
• prevent delayed nausea and vomiting that may occur several days after receiving chemotherapy medications

Emend is not used to treat nausea and vomiting that you already have.

Emend should not be used continuously for a long time (chronic use).

It is not known if Emend is safe and effective in children.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
 

• Merck Sharp & Dohme Corp.

In people taking Emend capsule to prevent nausea and vomiting caused by chemotherapy, the most common side effects include:

• tiredness
• nausea
• hiccups
• constipation
• diarrhea
• loss of appetite
• headache
• hair loss

In people taking Emend capsule to prevent nausea and vomiting after surgery, the most common side effects are:

• constipation
• nausea
• itching
• fever
• low blood pressure
• headache

In people taking Emend injection to prevent nausea and vomiting caused by chemotherapy, the most common side effects include:

• hiccups
• weakness or tiredness
• changes in liver function blood test results. Your doctor will check you for this.
• headache
• constipation
• loss of appetite
• indigestion
• diarrhea
• belching
• infusion site reactions (pain, hardening, redness, or itching at the site of injection)

This is not a complete list of Emend side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• anticoagulants ('blood thinners') such as warfarin (Coumadin)
• antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), and lansoprazole
• benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam (Versed), and triazolam (Halcion)
• diltiazem (Cardizem, Dilacor, Tiazac)
• cancer chemotherapy medications such as docetaxel (Taxotere), etoposide (Toposar, VePesid), ifosfamide (Ifex), imatinib (Gleevec), irinotecan (Camptosar), paclitaxel (Taxol), tamoxifen (Nolvadex), vinblastine, vincristine (Vincasar), and vinorelbine (Navelbine)
• carbamazepine (Tegretol)
• clarithromycin (Biaxin)
• diltiazem (Cardizem, Dilacor, Tiazac)
• HIV protease inhibitors such as nelfinavir (Viracept) and ritonavir (Norvir)
• hormonal contraceptives (birth control pills, patches, rings, and injections)
• nefazodone (Serzone)
• oral steroids such as dexamethasone (Decadron, Dexone)
• methylprednisolone (Medrol)
• paroxetine (Paxil, Pexeva)
• phenytoin (Dilantin)
• rifampin (Rifadin, Rimactane)
• tolbutamide (Orinase)
• troleandomycin (TAO)
• pimozide (Orap)
• terfenadine (Seldan)
• astemizole (Hismanal)
• cisapride (Propulsid)

This is not a complete list of all drug interactions. Ask your doctor or pharmacist for more information.

Emend may cause serious side effects, including:

• Serious allergic reactions. Allergic reactions can happen with Emend and may be serious. Stop taking Emend and call your doctor right away if you have any of these signs or symptoms of an allergic reaction:
  • hives
  • rash
  • itching
  • trouble breathing or swallowing.
• Severe skin reactions may occur rarely.

Do not take Emend if you:

• are allergic to any of the ingredients in Emend 
• are taking pimozide (Orap), terfenadine (Seldan), astemizole (Hismanal), or cisapride (Propulsid)

Taking Emend with any of these medicines could cause serious or life-threatening problems.

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of this medication, there are no specific foods that you must exclude from your diet.

Before you take Emend, tell your doctor if you:

• have liver problems
• are pregnant or plan to become pregnant. It is not known if Emend can harm your unborn baby. Women who use birth control medicines containing hormones to prevent pregnancy (birth control pills, skin patches, implants, and certain IUDs) should also use a back-up method of birth control during treatment with EMEND and for up to 1 month after using EMEND to prevent pregnancy.
• are breastfeeding

Tell your doctor about all the medicines you are taking or plan to take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category B. There are no well-done studies that have been done in humans with Emend. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Emend crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using this medication.

Take Emend exactly as prescribed.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

The recommended oral dosage of Emend for the postoperative nausea and vomiting (PONV) indication is 40 mg within 3 hours prior to induction of anesthesia.

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

• Storage requirements:
  • Capsule: Store at room temperature, between 68°F and 77°F (20°C and 25°C).
  • Injection: Store at 36-46°F (2-8°C)
• Keep Emend and all medicines out of the reach of children.